CFPs: Biomanufacturing of Bio-Based Chemicals, Biopolymers and Active Pharmaceutical Ingredients in Production Strains (India)

The Production strains for Biomanufacturing of bio-based chemicals / biopolymers/ APIs under the call are as follows:

• Talaromyces pinophilus L42
• Paenibacilluspolymyxa A18
• Saccharomyces cerevisiae NGY10
• Chlorella sorokiniana I
• Vibrio cholerae BB1
• Escherichia coli SSY05

Focus Areas

• The proposals should preferably focus on, but not restricted to the Biomanufacturing of the following bio-based chemicals/ biopolymers/Active Pharmaceutical Ingredients (APIs):
  • Bio-based Chemicals
    • Biosurfactants (Rhamnolipids, Sophorolipids)
    • Pigments (violacein, anthocyanin);
    • Flavor & fragrance (Nootkatone, valencene vanillin)
    • Squalene (with cosmetic and medical applications),
    • Itaconic acid (applications in plastic, paint, pharmaceutical, textile etc),
    • Methyl ethyl diol (applications in synthesis of polyester, antifreeze, lubricants).
  • Biopolymers
    • Bioplastic precursors (1,4-Butanediol; 2-3 Butanediol; Butanol, Succinic acid, Lactic Acid, Polyhydroxubutyrate, Polyhydroxyalkanotes, etc.)
    • Bio-Nylon precursors (Caprolactam; muconic acid; Adipic acid)
    • Biopolymers (Glycosaminoglycans; Polysaccharides)
  • APIs/KSMs/Drug Intermediates
    • Penicillin G,7-ACA, Erythromycin Thiocynate, Clavulanic Acid, Neomycin, Gentamycin, Betamethasone, Dexamethasone, Prednisolone, Rifampicin, Vitamin B1, Clindamycin Base, Streptomycin, Tetracycline, Lovastatin.

Categories

• The proposals are invited under the following two categories:
  • Discovery & Application-oriented Integrated Network Research:
    • The proposals under this category are invited for establishment of Proof-of– concept and early-stage validation in a bioreactor (upto100L) to eventually reach TRL 3-5 and will focus on:
      • Demonstration of bioproduction of metabolites
      • Outlining the minimal benchmark (titer/ productivity/scale) for the product
      • Strain/metabolic engineering for improved yield/titer of the metabolite.
      • Further development of a strain and toolkit to enable biomanufacturing.
  • Bridging the Gaps for Scale-up:
    • The proposals are invited for pilot-scale demonstration of technology in a bioreactor above 100 L to eventually reach TRL-7 or above and will focus on:
      • Use of simple sugars to effectively realize bioproduct development.
      • Optimization, upscaling and down-streaming (recovery & purification) of existing technologies.
      • Outlining the minimal benchmark (titer/productivity/scale) for the product.
      • Intensive strain engineering to further increase yield/titer of the bio-based chemical in an already up-scaled process.

Eligibility Criteria

• Companies established under the Companies Act 2013 and Startups.
• The Limited Liability Partnership (LLP) incorporated under the Limited Liability Partnership Act, 2008.
• Academic from various Institutions/Universities/Societies/ Trusts/NGOs/Foundations/ Voluntary Organizations, recognized as a Scientific and Industrial Research Organization (SIRO).

For more information, visit BIRAC.